IndraLab

Statements

Mutated KCNH2 activates potassium(1+). 2 / 2
| 2
reach
"Translation reinitiation in c.453delC frameshift mutation of KCNH2 producing functional hERG K+ channels with mild dominant negative effect in the heterozygote patient-derived iPSC cardiomyocytes."
37769355
reach
"In terms of electrophysiology, hERG mutations cause potassium ion channels to deactivate (close) much faster, blunting the normal rise in current (IKr) that results from rapid recovery from channel inactivation and slow deactivation [XREF_BIBR]."
22275999