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SCN5A binds GPD1L. 3 / 3
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"Using a heterologous expression system, we show that GPD1L associated with SCN5A and that the BrS- and SIDS related mutations in GPD1L caused a loss of enzymatic function resulting in glycerol-3-phosphate PKC dependent phosphorylation of SCN5A at serine 1503 (S1503) through a GPD1L dependent pathway."
19666841
sparser
"They demonstrated association of GPD1L with SCN5A; mutants of GPD1L increased PKC-mediated phosphorylation of SCN5A which in turn causes a dysfunction in sodium current, a mechanism for ventricular arrhythmias."
21685173
sparser
"Using a heterologous expression system, we show that GPD1L associated with SCN5A and that the BrS- and SIDS-related mutations in GPD1L caused a loss of enzymatic function resulting in glycerol-3-phosphate PKC-dependent phosphorylation of SCN5A at serine 1503 (S1503) through a GPD1L-dependent pathway."
19666841