IndraLab

Statements

OTUD3 inhibits AKT. 3 / 3
| 3
reach
"OTUD3 inhibits the activation of the AKT pathway by deubiquitinating PTEN and suppresses tumour progression in breast cancer (BC), colon cancer and cervical cancer [45]."
38685067
reach
"It is speculated that OTUD3 function may be impaired in SCCs, destabilizing the tumor suppressor PTEN and thus activating the AKT pathway to cause cancer (Gatti et al., 2020)."
37829187
reach
"MiR-520h binds to the 3′-untranslated region (3′-UTR) of OTUD3 and inhibits OTUD3 protein expression, which in turn inhibits PTEN expression and ultimately activates the downstream pathway AKT."
37829187