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Ethanol decreases the amount of IRS1. 5 / 5
1 | 4

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"Graphs, together with post hoc Tukey repeated measures tests demonstrated that ethanol significantly reduced the mean expression levels of Insulin R (XREF_FIG) and IRS-1 (XREF_FIG), but increased p70S6K (XREF_FIG) relative to control."

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"The present study showed that chronic ethanol intake could downregulate the expression levels of IR-beta, IRS-1, and Glut4 in rat cardiac muscles."

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"chronic ethanol intake at 2.5 and 5 xkg (-1) xd (-1) sufficient doses can down-regulate the expression of IRbeta, P-IRbeta, and IRS-1, as well as the phosphorylated forms of IRS-1 and Akt, in rat skeletal muscle, possibly through increased PTP1B activity."

No evidence text available

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"Chronic ethanol feeding significantly reduced the mean mRNA levels of insulin and IGF-1 polypeptides, insulin, IGF-1, and IGF-2 receptors, IRS-1, and IRS-2 (XREF_FIG)."