IndraLab

Statements

OTUD3 activates CGAS. 5 / 5
| 4 1
sparser
"Conversely, in antiviral immunity, OTUD3 stabilizes and activates cGAS by removing inhibitory ubiquitin chains, amplifying the cGAS-STING pathway and interferon responses."
41437362
reach
"Additionally, we found out that OTUD3 could also remove K27- and K29-linked polyUb from cGAS and elevate cGAS enzymatic activity, which are the complementary findings.Most intriguingly, we discovered [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
36966392
reach
"It is plain that cGAS has higher activity after treatment with OTUD3 WT than with OTUD3 CA ( Figures 5 A and 5B ), demonstrating that OTUD3 enhances cGAS enzymatic activity by deubiquitination.Because[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
36966392
reach
"Interestingly, the deubiquitinating enzyme OTUD3 promotes cGAS-mediated DNA sensing but inhibits RLR-mediated RNA sensing ."
37945923
reach
"Taken together, these data suggest that OTUD3 targets cGAS for deubiquitination in response to HSV-1 infection.Ectopic expression of OTUD3 increased the binding of cGAS to the DNA HSV120, a synthetic [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
35675783