IndraLab

Statements

Glucose decreases the amount of BAP1. 4 / 4
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"HG inhibits cystine uptake in podocytes by promoting the expression of BAP1 and inhibiting H2Aub deubiquitination on SLC7A11, a functional protein targeting cystine transporter system Xc-on the cell membrane, leading to the deposition of lipid peroxides and the occurrence of ferroptosis in podocytes."
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"HG inhibits cystine uptake in podocytes by promoting the expression of BAP1 and inhibiting H2Aub deubiquitination on SLC7A11, leading to lipid peroxide accumulation and ferroptosis in podocytes."
39816499
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"These findings suggest that HG inhibits cystine uptake by inhibiting SLC7A11 expression on the cell membrane, thereby influencing the regulation of ferroptosis.3.4 HG reduced SLC7A11 function by up-regulating BAP1 expression."
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"These results suggest that HG inhibits SLC7A11 function by promoting BAP1 expression, thereby inducing ferroptosis in podocytes.3.5 HG promotes ferroptosis by promoting BAP1 deubiquitination of H2Aub on SLC7A11."
39816499