The INDRA Database

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"Hence, USP4 positively regulates NF-kappaB signaling by deubiquitinating K48-ubiquitin chains of TRAF6 in EV71 infection [XREF_BIBR]."

33138315

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"Our findings provide novel insights into the molecular mechanisms by which USP4 positively regulates NF-kappaB signalling and thus plays a critical role in maintaining the balance between innate immune responses and immune tolerance."

30194441

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"Although USP4 / UNP is associated with the TNF response and activates NF-kappaB as shown with USP2a , it has a different role , wherein USP4 regulates TAK-1 stability upon TNF response ."

| PMC

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"In addition to these newly identified nuclear functions, both USP4 and USP15 are well known to function in the cytosol, i.e. USP4 modulates the Wnt and beta-catenin, NF-kappaB, p53 and TGF-beta signaling pathways while USP15 performs functions in the TGF-beta receptor and NF-kappaB signaling pathways."

27060135

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"It was also found that USP4 inhibited NF-kappaB activation, but in this study we confirmed that USP4 positively regulates the NF-kappaB signalling pathway during EV71 infection."

30194441

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"Therefore, to further confirm USP4 induced NF-kappaB activation, we designed and synthesized two siRNAs to knock down the intrinsic expression of USP4."

30194441

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"However, we found that EV71 infection inhibit the expression of USP4 to attenuate the activation of the NF-kappaB pathway, an example of an evolved mechanism through which EV71 antagonizes host defences."

30194441

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"Therefore, to further confirm USP4-induced NF-κB activation, we designed and synthesized two siRNAs to knock down the intrinsic expression of USP4."

30194441

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"These results suggest that deubiquitinating enzyme activity is responsible for the suppression of TNFα-mediated NF-κB activation by USP4."

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"Knockdown of USP4 promoted IL-1beta, LPS, and TGF-beta-induced NF-kappaB activation (Fan et al., 2011)."