IndraLab

Statements

Modified USP18 leads to the dephosphorylation of STAT1. 4 / 4
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"USP18 expression reduced STAT1 phosphorylation in STAT2 expressing U6A cells (XREF_FIG)."
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"In 2fTGH and U2A cells, USP18 expression clearly reduced STAT1 phosphorylation upon IFNalpha treatment (XREF_FIG), indicating that USP18 inhibits IFN signaling upstream of IRF9, as reported previously 21."
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"Silencing the expression of ISG15 or USP18 expression restored STAT1 phosphorylation and ISGs expression upon exogenous IFN-alpha treatment."
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"Since the STAT2-USP18 interaction is not affected by this mutation (XREF_SUPPLEMENTARY), USP18 expression still reduced phosphorylation of STAT1 in STAT2 Y690F expressing U6A cells stimulated with IFNalpha (XREF_FIG)."
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