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USP14 increases the amount of MDM2. 2 / 2

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"We further detected the change of MDM2-AR interaction using co-immunoprecipitation (co-IP), and found that USP14 inhibition or silence increased the binding of MDM2 to AR (XREF_FIG), suggesting that USP14 inhibits the degradation of AR by decreasing the expression and phosphorylation of MDM2."

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"Furthermore, USP14 selective inhibitor IU1 decreased MDM2 expression, inhibited growth, and triggered apoptosis in cervical cancer cells (Xu et al., 2020)."

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IndraLab

Statements

USP14 increases the amount of MDM2. 2 / 2

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