IndraLab

Statements


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"Pharmacological inhibition or knockdown of USP20 in HCC cells triggered ferroptosis and reversed OXA resistance both in vitro and in vivo."

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"Ubiquitin specific peptidase 20 (USP 20) maintains the stability of SLC 7A 11 protein by removing K48 linked polyubiquitination of SLC 7A 11 protein at K30 and K37, inhibits the occurrence of ferroptosis in liver cancer, and increases the tolerance to oxaliplatin (64)."

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"These results indicated that inhibition of USP20 by GSK2643943A could induce ferroptosis of HCC in vivo."

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"USP20 contributes OXA resistance and suppress ferroptosis in HCC."

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"Pharmacological inhibition or knockdown of USP20 triggered ferroptosis and increased the sensitivity of HCC cells to OXA both in vitro and in vivo."