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"In this study, we confirmed the interaction between USP8 and ASCL1 by Co-IP results and increased ubiquitination of ASCL1 after knockdown of USP8.Previous studies have found that CD47 is involved in osteoblast and stromal cell/osteoblast differentiation in mouse bone marrow cultures and that a lack of CD47 severely impairs SIRPα-dependent osteoblast differentiation and leads to a reduction in osteoclast formation (Koskinen et al. 2013)."