IndraLab

Statements

OTUB2 binds COV1. 6 / 6
| 6
sparser
"Further fragment analogue evaluation yielded the best inhibitor OTUB2-COV-1 ( xref ) with the k inact / K I value of 3.75 M −1 s −1 ."
34458789
sparser
"IsoTOP-ABPP demonstrated that OTUB2-COV-1 (10 μM compound, 2 h incubation) labeled <1% probe-accessible cysteines (Heavy/Light ratio >4) in HEK293T cells suggesting promising selectivity profile suitable for further development."
34458789
sparser
"Small molecule inhibitors for OTUB2 (OTUB2-COV-1) [ xref ] and USP4 (NR) [ xref ] have also been identified."
35204803
sparser
"Small molecule inhibitors for OTUB2 (OTUB2-COV-1) [102] and USP4 (NR) [103] have also been identified."
35204803
sparser
"Further fragment analogue evaluation yielded the best inhibitor OTUB2-COV-1 (Fig. 2C) with the kinact/KI value of 3.75 M−1 s−1."
34458789
sparser
"Recently, the first highly selective OTUB2 covalent inhibitor named OTUB2-COV-1 ( 38 , xref ) was identified by combining a new high-throughput thiol-reactivity assay with high-throughput crystallography [ xref ]."
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