IndraLab

Statements



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"It also has been shown to prevent palmitate induced IkappaBalpha degradation, RelA nuclear translocation, NO production, and cytokine secretion [XREF_BIBR], Besifloxacin is a novel fluoroquinolone initially developed by Bausch & Lomb for the topical treatment of ophthalmic infections [XREF_BIBR]."

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"C16 significantly decreased levels of phospho-IKKalpha / beta ( Figure 3A , 3B ) , phospho-p65 ( pp65 ) ( Figure 3A , 3C ) and phospho-IkappaBalpha , Figure 3A , 3D ) , and suppressed degradation of IkappaBalpha ( Figure 3A , 3E ) after LPS stimulation ."

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"Subsequently, we observed that oleate was able to partially prevent IkappaB-alpha degradation induced by TNF-alpha or palmitate."

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"Myoblasts treated with palmitate exhibit activation of pathways leading to inflammation, specifically activating MAPK, elevating ROS and inducing IkappaBalpha degradation."

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"Additionally, the combination of palmitate and LPS also reduced IkBalpha at 60 min and IkBbeta in cytoplasm at 10 min."

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"The co-treatment with 400muM linoleate inhibited phospho-c-Jun N-terminal kinase (pJNK) activation and IkBalpha reduction caused by 500muM palmitate treatment."