IndraLab

Statements

USP7 inhibits DNA Damage. 9 / 9
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"Our results indicate that inhibition of USP7 leads to a disruption of cell cycle progression, and triggers DNA damage and apoptosis."
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"3.5 Inhibiting USP7 triggers DNA damage in canine lymphoma and leukemia cell lines."
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"Overall, the data show that inhibition and overexpression of USP7 both compromise DNA repair of radiation-induced DNA damage, particularly in the S phase."
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"Given that USP7 is essential for maintaining DNA damage tolerance [ 16 , 17 ], we hypothesized that depletion of USP7 could increase the level of DNA damage."
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"This demonstrates that USP7 knockdown increases DNA damage accumulation in mouse embryos.Because elevated DNA damage tends to induce apoptosis, we next performed TUNEL assay to detected the level of a[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"These indicated that DNA damage and blastocyst cell apoptosis caused by USP7 knockdown might be the cause of embryo development arrest.H3K27me3 is one of important epigenetic modifications during prei[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Previous results have demonstrated that inhibition of USP7 induces genotoxic stress and DNA damage in chronic lymphocytic leukemia (CLL) cells."
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"We have found that depletion of USP7 caused DNA damage, abnormal H3K27me3, which leads to early embryo apoptosis and early embryo development arrest ( Fig. 6 )."
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"Inhibition of USP7 caused DNA damage in chronic lymphocytic leukemia cells, leading to tumor cell death [30]."
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