IndraLab

Statements

USP7 inhibits DNA Damage. 4 / 4
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"Our results indicate that inhibition of USP7 leads to a disruption of cell cycle progression, and triggers DNA damage and apoptosis."
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"3.5 Inhibiting USP7 triggers DNA damage in canine lymphoma and leukemia cell lines."
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"Previous results have demonstrated that inhibition of USP7 induces genotoxic stress and DNA damage in chronic lymphocytic leukemia (CLL) cells."
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"Here, we report that in response to DNA damage USP7 is downregulated by the ATM dependent protein phosphatase PPM1G, thus downregulating Mdm2 and activating the p53 response."
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