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USP2 activates cell growth. 2 / 3

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"To completely exclude the possibility that the cell growth repression induced by USP2 knockdown is p53 dependent, we performed the same experiments in isogenic p53 knockout cells (HCT116 p53-/-)."

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"Again, knockdown of USP2 in MCF-7 and PC3 cells significantly reduced the steady state levels of cyclin D1 protein (XREF_FIG, also in XREF_SUPPLEMENTARY) and also induced cell growth suppression (XREF_FIG)."

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IndraLab

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USP2 activates cell growth. 2 / 3

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