IndraLab

Statements

USP10 activates FLT3. 6 / 6
| 6
reach
"Intriguingly, USP10 inhibition has been shown to promote oncoprotein FLT3 degradation, suggesting that USP10 could be considered as a potential pharmacological target for fighting FLT3- mutant AML disease [XREF_BIBR]."
32674429
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"USP10 inhibition leads to death of cells driven by active SYK or oncogenic FLT3 and potentiates the anti-leukemic effects of FLT3 inhibition in these cells."
32015510
reach
"A more recent study revealed that USP10, a deubiquitinating enzyme, is essential for the stabilization of FLT3 protein and inhibition of USP10 induces the degradation of FLT3/ITD, as well as FLT3/TKD, albeit to a lesser extent [42]."
30250637
reach
"Inhibition of USP10 induces degradation of oncogenic FLT3."
28967922
reach
"It was recently reported that inhibition of USP10 also induces degradation of FLT3/ITD [42]."
30250637
reach
"In addition, we show that USP10 inhibition potentiates the effects of FLT3 inhibition in cells driven by activated SYK."
32015510