IndraLab

Statements

USP10 activates FLT3. 6 / 6
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"A more recent study revealed that USP10, a deubiquitinating enzyme, is essential for the stabilization of FLT3 protein and inhibition of USP10 induces the degradation of FLT3/ITD, as well as FLT3/TKD, albeit to a lesser extent [42]."
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"In addition, we show that USP10 inhibition potentiates the effects of FLT3 inhibition in cells driven by activated SYK."
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"It was recently reported that inhibition of USP10 also induces degradation of FLT3/ITD [42]."
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"Intriguingly, USP10 inhibition has been shown to promote oncoprotein FLT3 degradation, suggesting that USP10 could be considered as a potential pharmacological target for fighting FLT3- mutant AML disease [XREF_BIBR]."
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"USP10 inhibition leads to death of cells driven by active SYK or oncogenic FLT3 and potentiates the anti-leukemic effects of FLT3 inhibition in these cells."
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"This stabilizing action enhances FLT3 downstream signaling, promoting cell proliferation and survival, and thus highlighting USP10′s potential as a therapeutic target in FLT3-driven leukemias.In breas[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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