IndraLab

Statements

reach
"Inhibition of USP7 upregulates E-cadherin and downregulates Vimentin and N-cadherin, indicating USP7 promotes EMT in NSCLC."
28166483
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"Experimental results showed that USP7 overexpression suppressed the expression of several pathway-related genes, including Wnt, promoting cellular EMT and inhibiting cellular senescence and differentiation (128–130)."
40337608
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"Inhibition of USP7 activity repressed proliferation, induced apoptosis, suppressed migration and invasive activities, and reversed the epithelial-mesenchymal transition of ERPBC."
39985032
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"Our findings demonstrated that the residues located between 446 and 578 within the C-terminal region of Pol ι are essential for the deubiquitination, stabilization, and functional activity of HIF-1α and blocking the specific binding of Pol ι and USP7 inhibits HIF-1α induced EMT in ESCC cells (Fig. 7)."
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