IndraLab

Statements

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"When ROS levels further increase, such as in AD, oxidation of KCNB1 may become exacerbated and promote neuronal apoptosis."
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"Cleavage of Kv2.1 by BACE1 decreases potassium current and reduces neuronal apoptosis."
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"Oxidative modification of the voltage gated potassium (K +) channel KCNB1 promotes apoptosis in the neurons of cortex and hippocampus through a signaling pathway mediated by Src tyrosine kinases."
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"In response to oxidative stress, amplification of an outward K(+) current mediated by the Kv2.1 channel, precedes the onset of apoptosis."
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"Pharmacological inhibition of integrin signaling or FAK suppressed apoptosis induced by oxidation of KCNB1, as well as FAK and Src and Fyn activation."
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"Overexpression of K v 2.1 in HEK293 cells increases their vulnerability to oxidant-induced apoptosis, and this is reversed by CO."
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"The results of our present study that Kv2.1 transfection increase HEK293 cells apoptosis after OGD treatment and K + channel blocker TEA attenuated OGD induced Kv2.1/HEK93 cells apoptosis confirmed th[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"XREF_BIBR, XREF_BIBR If integrins are responsible for the apoptotic stimulus, pharmacologically inhibiting integrin signaling should prevent apoptosis induced by oxidation of KCNB1, whereas inhibiting integrin signaling in cells expressing C73A should have only minor effect on their viability."
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"Moreover, pharmacological inhibition of integrin signaling in primary neurons and CHO cells was protective against apoptosis induced by oxidation of KCNB1."
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"KCNB1 oxidation acts to enhance apoptosis in mammalian cell lines, whereas a KCNB1 variant resistant to oxidative modification, C73A-KCNB1, is cytoprotective."
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"Accordingly, cholesterol supplementation reduced apoptosis promoted by oxidation of KCNB1."
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"Together, these data suggest that the accumulation of KCNB1 oligomers in the membrane disrupts planar lipid raft integrity and causes apoptosis via activating the c-Src and JNK signaling pathway."
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"In contrast, overexpression of Kv2.1 channels increases their susceptibility to apoptosis ( Pal et al., 2003 )."
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"Therefore, inhibition of Kv2.1 currents may suppress apoptosis and improve cell survival."
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"Furthermore, we demonstrated that the BACE1-cleaved Kv2.1 reduces neuronal apoptosis and BACE1 inhibitor markedly increases neuronal apoptosis."
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"Notably, microglial Kv2.1 specific knockdown suppressed o-Aβ-induced neuronal apoptosis on brain slices, while Dfe exhibited still neuroprotective effects by comparing (o-Aβ+Dfe)-treated to o-Aβ-treated groups in MG-Kv2.1-KD brain slices (Fig. S5B and S5C)."
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"Pharmacological inhibition of integrin signaling or FAK suppressed apoptosis induced by oxidation of KCNB1, as well as FAK and Src and Fyn activation."
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"Oxidant induced oligomerization of wild-type KCNB1 enhanced apoptosis in neuronal cells subject to oxidative insults."
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"Overexpression of Kv2.1 in HEK293 cells increases their vulnerability to oxidant induced apoptosis, and this is reversed by CO ( Dallas et al., 2011 )."
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"KCNB1 oxidation promotes inflammation, oxidative stress, neuronal apoptosis, and behavioral deficit in mouse model of traumatic brain injury a condition that, likewise AD, is associated to copious release of ROS 7."
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"Abstract Oxidative modification of the voltage gated potassium (K +) channel KCNB1 promotes apoptosis in the neurons of cortex and hippocampus through a signaling pathway mediated by Src tyrosine kinases."
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