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USP12 inhibits cytokine-mediated signaling pathway. 1 / 1
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"Gene ontology (GO) analysis revealed that the pathways significantly enriched in USP12-downregulated genes were mostly related to cytokine-mediated signalling pathway and immune effector process (Fig. 3a); further in-depth examination showed that USP12 expression decreased levels of a number of chemokine, such as CXCL8, CXCL1, CXCL2, CCL2 and CCL5, most of which were associated with immune cell recruitment (Fig. 3b and Supplementary Fig. 2a)."