IndraLab

Statements

ERK inhibits CYLD. 3 / 3
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"BRAF mediated ERK activation induced Snail1 and down-regulated CYLD in melanoma cells."
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"Moreover, we demonstrate that suppression of CYLD by ERK1/2 signaling plays an important role in maintaining RIP1 expression, and that melanoma cells with acquired resistance to BRAF inhibitors are more critically dependent on RIP1 for survival."
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"Moreover, silencing of ERK1/2 caused downregulation of Snail1 and upregulation of CYLD, whereas silencing of Snail1 recapitulated the effect of ERK1/2 silencing on the expression of CYLD and RIP1 in Mel-CV."
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