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Streptozocin inhibits NLRP3. 3 / 3
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"NLRP3 knockout (NKO) mice were induced to diabetes by intraperitoneal injections of streptozotocin (STZ)."
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"In addition to showing allopurinol reduced oxidative stress markers, NLRP3, and IL-1β, a streptozotocin-induced diabetic rat model revealed that allopurinol administration decreased hyperglycemia-induced retinal leukostasis, and restored retinal blood-barrier function (15)."
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"We tested the hypothesis that mDNA contributes to diabetes-associated endothelial dysfunction and vascular inflammation via NLRP3 activation.Methods: Vascular reactivity, reactive oxygen species (ROS) generation, calcium (Ca 2+ ) influx and caspase-1 and IL-1beta activation were determined in mesenteric resistance arteries from normoglicemic and streptozotocin-induced diabetic C57BL/6 and NLRP3 knockout (Nlrp3 -/- ) mice."
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