IndraLab

Statements

KCNK2 activates MCP-1. 5 / 5
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"Interestingly, while TREK-1 deficiency resulted in decreased IL-6 and increased MCP-1 secretion from both mouse [XREF_BIBR] and human alveolar epithelial cells [XREF_BIBR, XREF_BIBR], overexpression of TREK-1 had no further effect on MCP-1 secretion when compared to control cells [XREF_BIBR]."
26001192
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"We found that TREK-1 deficiency altered the cytokine release profile of alveolar epithelial cells upon TNF-alpha stimulation, resulting in decreased IL-6 and increased MCP-1 secretion [XREF_BIBR, XREF_BIBR]."
25126877
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"In summary, we report for the first time that TREK-1 deficiency in human AECs resulted in increased MCP-1 production and secretion, and this effect appeared unrelated to alterations in JNK-, PKC- or Ca (2+)-mediated signaling pathways in TREK-1 deficient cells."
23977412
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"We recently reported the expression of K2P channels in alveolar epithelial cells (AECs) and found that TNF-alpha stimulation of TREK-1 deficient AECs caused decreased IL-6 secretion but increased MCP-1 secretion in vitro [XREF_BIBR, XREF_BIBR]."
25126877
reach
"In contrast to IL-6 secretion, we found that TREK-1 deficiency resulted in increased MCP-1 production and secretion, although baseline MCP-1 gene expression was unchanged in TREK-1 deficient cells."
23977412