IndraLab
Statements
sparser
"When testing for a gene–gene interaction using a random effects two-way ANOVA model of the novelty encoding contrasts (subsequently recognized novel scenes compared with the master images), we could replicate the complex interaction of CACNA1C rs1006737 and PCLO rs2522833 observed in the first two experiments, with carriers of either no or both high-risk alleles showing higher CG25 activation relative to carriers of either rs1006737 A or rs2522833 C alleles, but not both (F 1,105 =14.62; P =0.039, FWE-corrected for CG25 ROI volume; xref )."
sparser
"We observed a complex gene–gene interaction of CACNA1C rs1006737 and PCLO rs2522833 in CG25, with participants homozygous for the low-risk allele of both SNPs and carriers of both high-risk alleles showing higher CG25 activation during self-reference when compared with carriers of only one high-risk allele (either CACNA1C rs1006737 A or PCLO rs2522833 C, but not both; F 1,71 =13.50; P =0.034, FWE-corrected for CG25 ROI volume; see xref )."
sparser
"Summarizing the results of the three experiments, we could observe a gene–gene interaction between CACNA1C rs1006737 and PCLO rs2522833 in CG25 where carriers of no risk allele and carriers of both risk alleles exhibited higher activation relative to carriers of only one risk variant during episodic encoding relative to baseline."