IndraLab

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BRCC3 increases the amount of GPX4. 3 / 3
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"Moreover, overexpression of BRCC36 upregulated the expression of HMGCR and GPX4 in HepG2 cells treated with LPS and Nig (Figure S3C, Supporting Information)."
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"We found that BRCC36 overexpression upregulated the expression of GPX4 and HMGCR, while decreasing the levels of 4‐HNE (4‐hydroxy‐2‐noneal), a biomarker of ferroptosis (Figure 6I,J), indicating BRCC36 inhibits ferroptosis in HCC."
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"BRCC36 overexpression also rescued the low expression of HMGCR and GPX4 caused by RSL3 in HepG2 cells (Figure S5B, Supporting Information)."
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