IndraLab

Statements

BAP1 increases the amount of BRCA1. 5 / 5
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"XREF_BIBR previously suggested that BAP1 enhanced BRCA1 mediated inhibition of cancer cell growth, although they did not directly establish the possibility that BAP1 enhances the BRCA1 protein level."
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"BAP1 mediated growth suppression is independent of wild-type BRCA1 expression."
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"Noticeably, we found that exogenous BAP1 significantly increased the BRCA1 protein level."
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"Although BRCA1 expression significantly decreased in an MM cell line with BAP1 deletion, Y-MESO-25, the transduction of the WT and even mutant forms of BAP1 induced upregulation of the BRCA1 protein level."
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"It is worth noting that BAP1 can restore the protein expression of BRCA1."
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