IndraLab

Statements

BAP1 increases the amount of BRCA1. 10 / 10
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"Importantly, artificial upregulation of BAP1 restored the protein level of BRCA1 in cells, while it had little effect on the BRCA1 mRNA expression.Following the findings above, we then focused on the [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Importantly, it was found that overexpression of BAP1 in the RTECs significantly elevated the protein level of BRCA1 and suppressed phosphorylation of NF-κB, though it did not affect the total protein[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"It is worth noting that BAP1 can restore the protein expression of BRCA1."
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"BAP1 depletion reduced the quantity of both RAD51 and BRCA1 foci without affecting the respective protein levels and exerted no effect on the formation of 53BP1 or autophosphorylated DNA-PK foci, suggesting that BAP1 functions in HR but not in NHEJ ."
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"Noticeably, we found that exogenous BAP1 significantly increased the BRCA1 protein level."
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"XREF_BIBR previously suggested that BAP1 enhanced BRCA1 mediated inhibition of cancer cell growth, although they did not directly establish the possibility that BAP1 enhances the BRCA1 protein level."
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"Although BRCA1 expression significantly decreased in an MM cell line with BAP1 deletion, Y-MESO-25, the transduction of the WT and even mutant forms of BAP1 induced upregulation of the BRCA1 protein level."
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"Indeed, previous global mRNA expression profiling suggests that BAP1 depletion can perturb BRCA1 mRNA levels [27]."
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"BAP1 mediated growth suppression is independent of wild-type BRCA1 expression."
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"BAP1, a member of the DUB family, has been shown to directly up-regulate the expression of BRCA1, a tumor suppressor in cancer cells [153] ."
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