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"When Apc min/+ mice were treated with the specific hERG1 blocker E4031, daily for 3months, such long-term mERG1 current inhibition XREF_BIBR - XREF_BIBR, that, in agreement with a previous paper XREF_BIBR, did not lead to drug induced torsades de pointes in E4031 treated mice, produced an impairment in colonic lesion development."