IndraLab

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"Our data indicated that quercetin and aspirin effectively downregulated caspase-1, NLRP3, apoptosis-associated speck-like protein containing a caspase recruitment domain, and pro-caspase-1 (Fig. 5A–G) on both mRNA and protein levels."
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"Through colocalizing NLRP3/caspase-1 by immunofluorescence, we found that aspirin at low concentration and high concentration inhibited the formation of NLRP3 inflammasome, but the effects of dexamethasone and aspirin at middle concentration were not obvious (Fig. 6A and B)."
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"Another study showed that aspirin, known for decades to have anti-inflammatory effects, inhibits NLRP3 activation in mice vascular endothelial cells."
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"And one of the interesting phenomena is the low-dose and high-dose aspirin both can restore the endothelial dysfunction, but the low dose can inhibit the activation of NLRP3 inflammasome, the high doses of aspirin have no effect."
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"Another modifier of the present results might have been medication status, as our population was heavily medicated, and, e.g., aspirin is known to downregulate the NLRP3 inflammasome [20], whereas statin may both stimulate and inhibit the inflammasome, partly dose-dependent [21]."
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"Meanwhile, the efficacy of aspirin in inhibiting the activation of NLRP3 inflammasomes and restoring endothelial homeostasis by inhibiting NLRP3 inflammasomes has been confirmed in vitro and in vivo."
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"Due to the antioxidant and anti-inflammatory properties of the aspirin, we hypothesized that the aspirin suppresses the NLRP3 inflammasome by inhibiting the ROS/TXNIP pathway, so we selected LPS as the stimulus."
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"In addition, aspirin inhibits the activation of NLRP3 inflammasome in a dose-dependent manner, restores endothelial barrier and permeability, and improves microvascular endothelial dysfunction (55).4.1.2 Anti-myocardial ischemia and angina drugs."
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"It was reported that low-concentration aspirin could inhibit the formation and activation of NLRP3 inflammasome [51]."
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"We also found that aspirin can interdict the ROS/TXNIP pathway to inhibit activation of the NLRP3 inflammasome.Clinically, it has been verified that long-term use of low-dose aspirin mitigates cardiovascular diseases, but the signaling pathways is still unclear."
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"As the data shown, we confirmed that aspirin can effectively inhibit the formation and activation of NLRP3 inflammasome (Fig. 2)."
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"We demonstrated that low-concentration aspirin inhibits the NLRP3 signaling pathway to alleviate endothelial dysfunction (Fig. 3), because ZO1/ZO2 of gNlrp3 cells has no significant change in the normal group, model group, or administration group."
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"APAP-induced DILI is protected by aspirin and benzyl alcohol, which inhibit the activation of NLRP3 inflammasomes and neutrophil infiltration (75, 76)."
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