IndraLab

Statements

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"TBHQ treatment markedly inhibited the activation of the NLRP3 inflammasome in PA-treated HK-2 cells, as characterized by decreased NLRP3, caspase-1."
38720901
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"TBHQ is reported to inhibit NLRP3 inflammasome activation and consequent IL-1beta production and secretion in cerebral ischemia reperfusion injury of rats XREF_BIBR."
30014902
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"Consistent with all these studies, we have shown that 24 h treatment with tBHQ prior to NLRP3 inflammasome activation reduces NLRP3 inflammasome components both in WT and NOX4 KO mice (Figure 4)."
37760032
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"TBHQ can also inhibit the expression and activation of cell death–related proteins, i.e., NLRP3, Caspase-1, IL-18, Pro-IL-1β, and IL-1β, and there was a significant decrease in TUNEL + and NLRP3 + co-positive cells in the alveoli."
37556072
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"Clinically, the NLRP3 inflammasome could be a crucial therapeutic target for nasal diseases caused by PM exposure.We confirmed that tBHQ inhibits the NLRP3 inflammasome, thereby alleviating pyroptosis."
38922087
eidos
"We found that tBHQ reduced NLRP3 , p65 and TXNIP and increased TRX expression in aged EPCs ( Figure 6E , 6H , 6I ) , while silencing Nrf2 in young EPCs upregulated NLRP3 , p65 and TXNIP and downregulated TRX expression ( Figure 6E , 6J , 6K ) ."
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