IndraLab

Statements

USP50 binds AS-C. 7 / 7
| 7
sparser
"Coimmunoprecipitation assays indicated that USP50 strongly binds to the ASC adaptor protein, although it also interacted weakly with NLRP3 (Fig. xref A)."
28094437
sparser
"Therefore, these results show that the binding of USP50 with ASC protein to deubiquitinate K63‐linked polyubiquitination is a crucial step for inflammasome activation."
28094437
sparser
"Mechanically, USP50 physically interacts with ASC, reducing its K63-linked ubiquitination and enhancing ASC oligomerization, subsequently promoting the assembly and activation of the NLRP3 inflammasome."
38469295
sparser
"USP50 binds to the ASC adaptor protein and is required for NLRP3‐induced ASC speck formation and oligomerization."
28094437
sparser
"Further investigations revealed that USP50 interacts with ASC proteins and deubiquitinates K63-linked ASC polyubiquitination ( xref )."
40028334
sparser
"Based on the interaction between USP50 and ASC protein, we next investigated whether USP50 knockdown affects inflammasome activation by analyzing the formation of ASC specks."
28094437
sparser
"A recent report further suggested that USP50 binds ASC and deubiquitinates K63-linked polyubiquitin chains on ASC (citation)."
29031697