IndraLab

Statements

USP4 is phosphorylated. 5 / 5
| 5
rlimsp
"AKT-mediated phosphorylation of USP4 at a consensus motif stabilizes this DUB, which in turn deubiquitinates the TGFβ-induced activated TβRI and leads to the stabilization of downstream activation of phosphorylated SMAD2 and SMAD2/SMAD4 complex formation (Fig. 2)."
28166483
rlimsp
"Phosphorylated USP4 translocates to the membrane, binds and stabilizes type I receptor."
25606592
rlimsp
"The authors also observed phosphorylation of endogenous USP4 upon the addition of TGF-β."
28425962
rlimsp
"DUBs may also contribute to the crosstalk between different pathways, as illustrated by USP4, which is regulated by Akt-mediated phosphorylation and deubiquitinates the TGFβ-I receptor [39]."
23937906
rlimsp
"They further showed that USP4 could interact with Akt at endogenous level, and phosphorylate USP4 in vitro and in vivo."
28425962