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SOX9 increases the amount of USP22. 3 / 3
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"In this study, we reported that ZRANB1 enhanced the features of CSCs and accelerated tumor progression by regulating the stability of Sox9 protein, which then mediated USP22 transcription and the acti[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"The upregulation of Sox9 induced mRNA expression of USP22 in CRC cells, whereas Sox9 knockdown led to significantly decreased USP22 expression compared to the control cells ( Fig. 5 A )."
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"In HCT116 and SW620 cells, the downregulation of ZRANB1 significantly suppressed the expression of USP22, while the overexpression of Sox9 restored the mRNA and protein levels of USP22 in CRC cells ( [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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