IndraLab

Statements

TNF activates COPS5. 2 / 2
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"Collectively, our results suggested that the pro inflammatory cytokine TNF-alpha, secreted by macrophages, upregulates CSN5 to stabilize PD-L1, thereby enhancing its interaction with PD-1 to escape T cell immune surveillance (XREF_FIG)."
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"Alternately, COP9 signalosome subunit 5 (CSN5), as a deubiquitinase, is upregulated by the tumor necrosis factor alpha (TNF‐α)/nuclear factor‐kappa B (NF‐κB) network in response to chronic inflammation, leading to PD‐L1 protein stabilization and impairment of the anticancer therapy in breast cancer cells [23]."
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