IndraLab

Statements

OTUB1 is dephosphorylated. 9 / 9
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"ODN induced phosphorylation of SHP2 (Y542) and dephosphorylation of Src (Y416) and OTUB1 (Y26) resulting in Raptor destabilization."
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"Moreover, inhibition of cathepsin K (by ODN and siRNA) significantly increased SHP2 phosphorylation at Y542, and SHP2 inhibition (by using pharmacological inhibitor and siRNA) interrupted the ODN-mediated dephosphorylation of OTUB1 and Src, eventually stabilizing Raptor (Fig. 2C–F)."
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"ODN alone and combined treatment with ODN plus oxaliplatin induced phosphorylation of Syk and SHP2, dephosphorylation of Src and OTUB1, and downregulation of Raptor (Fig. xref )."
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"Moreover, inhibition of cathepsin K (by ODN and siRNA) significantly increased SHP2 phosphorylation at Y542, and SHP2 inhibition (by using pharmacological inhibitor and siRNA) interrupted the ODN-mediated dephosphorylation of OTUB1 and Src, eventually stabilizing Raptor (Fig. xref )."
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"However, dephosphorylation of OTUB1 destabilized Raptor and sensitized cancer cells to anti-cancer drugs via mitochondrial reactive oxygen species-mediated mitochondrial dysfunction."
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"We observed that siRNA and pharmacological inhibitors (Entospletinib and PRT062607) of Syk reduced ODN-induced SHP2 phosphorylation (Y542), OTUB1 dephosphorylation (Y26), and Raptor downregulation (Fig. xref )."
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"In ODN-treated cells, Syk, a tyrosine kinase, activates SHP2 resulting in the induction of dephosphorylation of Src and OTUB1."
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"SHP2 is a key determinant of ODN-induced Raptor degradation through OTUB1 dephosphorylation."
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"Furthermore, overexpression of Syk induced phosphorylation of SHP2 (Y542), dephosphorylation of Src (Y416) and OTUB1(Y26), and downregulation of Raptor (Fig. xref )."
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