IndraLab

Statements

PIM inhibits OTULIN. 2 / 2
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"Phosphorylation of Tyr56 within the PIM abrogates this interaction and the ability of OTULIN to antagonize NF-κB signaling.The activity of the NF-κB-associated DUB CYLD is negatively affected by both [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Importantly, mutation of the cornerstone residue Asn102 to Asp (N102D) or a mutation that affect the hydrophobic PIM pocket (Y82A) reduced the ability of OTULIN to antagonize LUBAC induced NFkappaB activity in comparison to wild-type HOIP (XREF_FIG D)."
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