IndraLab

Statements

USP47 binds YAP1. 11 / 11
1 | 2 8
sparser
"In co-immunoprecipitation (Co-IP) assays, recombinant USP47 could pull-down YAP and vice versa , suggesting that USP47 and YAP physically interact with each other (Fig.  xref A)."
31748975
biogrid
No evidence text available
29891922
sparser
"In summary, we uncovered an USP47-YAP signaling axis in regulating the development of CRC."
31748975
reach
"USP7 and USP47 share substrates such as the Yes-associated protein (YAP), which functions as the main effector of the Hippo pathway ."
37740002
sparser
"Taken together, these results indicate that YAP physically interacts with USP47, and USP47 serves as a DUB for YAP."
31748975
sparser
"In addition, USP47 interacts with YAP, promotes YAP transcriptional activity and protein stability, and is the interactor for β-Trcp, an E3 ubiquitin ligase, leading to NLR family pyrin domain-containing (NLRP)3 proteasomal degradation via Lys27-linked polyubiquitination at Lys380."
35145062
sparser
"USP47 interacts with YAP, facilitating its deubiquitination and thereby stabilizing YAP."
41258572
reach
"It has also been observed by Pan et al that USP47 can interact with, deubiquitinate, and stabilize YAP to activate the pro-regenerative Hippo signaling pathway [ 46 ]."
37487274
sparser
"This suggests that the USP47-YAP signalling axis in the Hippo pathway may mediate NLRP3 activation and regulate immune and inflammatory responses."
35145062
sparser
"To verify this hypothesis, we first tested the interaction between USP47 and YAP."
31748975
sparser
"In addition, the USP47-YAP signaling axis can promote CRC cell invasion by protecting YAP from degradation by proteases, increasing YAP expression [ xref ]."
38339403