IndraLab

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USP5 decreases the amount of TP53. 9 / 9
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"Silencing of either BECN1 or USP5 significantly increased nuclear p53 expression (Fig. 4h, i)."
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"Additionally, USP5 knockdown increased levels of p53 but not MDM2, increased p53 activity and increased transcription of p53 target genes."
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"Usp5 links suppression of p53 and FAS levels in melanoma to the BRAF pathway."
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"In contrast, USP5 overexpression decreased the level and activity of p53 and inhibited transcription of p53 target genes."
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"Consequently, inhibition of USP5 leads to an accumulation of unanchored polyubiquitin chains within cells and a reduction in monomeric ubiquitin, increasing p53 levels in a dose-dependent manner and suppressing tumor formation."
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"In addition, inhibition of USP5 caused its substrate to compete with ubiquitinated p53 for proteasome and increased the level of p53 [ 93 ]."
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"Notably, silencing of USP5 dramatically upregulated levels of p53 and p21, a p53 downstream cell cycle inhibitor, concomitant with induced cellular senescence and inhibited colony formation of A549 and H292 cells (Fig. 1c–e and Supplementary Fig. S2a)."
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"In the meanwhile, in melanoma, deletion of USP5 upregulates p53 and p73 levels and suppresses the G2/M phase cell cycle checkpoint associated with p21; USP5 knockdown upregulates the expression of p53[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Suppression of USP5/isopeptidase T has been shown to increase both the levels and transcriptional activity of p53 without altering Mdm2 stability ( Dayal et al., 2009 )."
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