IndraLab

Statements

USP25 inhibits TNF. 3 / 3
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"Indeed, deletion of USP25 significantly increased the production of TNF-α, IL-1β, and IL-6 in both SV40 cells and BMDMs upon stimulation with AGEs in vitro ( Fig. 7 A-F), confirming the in vivo findin[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Of note, in USP25 -/- T1DM mice, USP25-deficient macrophages produced more TNF-α in the kidney than USP25-sufficient macrophages in USP25 +/+ T1DM mice ( Fig. 5 C)."
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"In this study, we found that overexpression of USP25 negatively regulated IL-17- but not TNF triggered signaling."
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