IndraLab

Statements

reach
"Meanwhile, the enhanced apoptosis induced by USP44 knockdown was also accompanied by increased caspase-3 and PARP activation, which are essential effectors in apoptotic pathways.WDR5, an oncogene often found in cancers, is associated with the proliferation, cell cycle, and apoptosis of cancer cells 29-32."
36483601
reach
"For example, BAX, a major proapoptotic protein [22], is upregulated in USP44-overexpressing OSCC cells, implying that USP44 may inhibit OSCC progression by promoting apoptosis."
39722007
reach
"The decreased expression of USP44 in colorectal cancer was also reported in the study by Huang et al (74), where USP44, as a tumor suppressor, was demonstrated to inhibit the Wnt/β-catenin pathway and promote the apoptosis of colorectal cancer cells through the deubiquitination of axin 1.Renal clear cell carcinoma is the most common type of renal carcinoma."
36380875
reach
"We speculated that USP44 could also be associated with the immune escapes of T-ALL cells, which needs further investigation.Collectively, in the present study, USP44 contributed to the growth of leukemia cells and suppressed their apoptosis."
36483601
reach
"The results showed that USP44 overexpression increased Axin1 protein while reducing β-catenin, c-myc and cyclin D1 protein, indicating that USP44 inhibited the activation of Wnt/β-catenin pathway mediated CRC cell apoptosis [41]."
35836256
reach
"Knockdown of USP44 induced the apoptosis of T-ALL cells."
36483601
reach
"These results depicted that the knockdown of USP44 induced the apoptosis of T-ALL cells."
36483601
reach
"Moreover, the cell apoptosis, induced by USP44 knockdown, was suppressed by WDR5 overexpression (Figure 4H)."
36483601
reach
"USP44 suppresses proliferation and enhances apoptosis in colorectal cancer cells by inactivating Wnt and beta-catenin pathway via Axin1 deubiquitination."
32285989
reach
"Knockdown of USP44 inhibited proliferation, migration and invasion, induced apoptosis, and arrested cell cycle in G2/M phase in the established glioma cell lines."
28938551
reach
"However, USP44 knockdown induced apoptosis in Jurkat and MOLT-4 cells, with an upheaval among cleaved caspase-3 and PARP levels."
36483601
reach
"Interestingly, WDR5 overexpression abolished the apoptosis induced by USP44 knockdown."
36483601
reach
"Interestingly, USP44 induced the apoptosis of colon cancer cells 11, while suppressed the apoptosis of glioma 8. In our study, we demonstrated that USP44 knockdown elevated the apoptosis of T-ALL cells, revealing a suppression role of USP44 during the apoptosis of T-ALL cells."
36483601