IndraLab

Statements

ADAM15 binds IL2RG. 3 / 3
| 3
sparser
"Since it is known that γC binds and activates endothelial αvβ3, a transmembrane integrin receptor involved in intracellular signaling mediated by the tyrosine kinases FAK and Src, we hypothesized that γC alters endothelial barrier function by activating the FAK-Src pathway leading to junction dissociation and RhoA driven cytoskeletal stress-fiber formation."
32352989
sparser
"The current study supports a direct binding interaction between γC and αvβ3."
19122172
sparser
"Since FAK has be implicated in integrin-mediated barrier dysfunction [ xref ] and previous experiments denote the binding of γC to integrin αvβ3 [ xref ], we sought to deduce the role of FAK in γC-induced microvascular hyperpermeability."
32352989