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LEP increases the amount of USP2. 9 / 10
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"Based on our results, it is highly likely that USP-2 suppression by adiponectin enhanced proteasomal activity, thereby increasing cyclin D1 degradation, whereas enhancement in USP-2 expression by lept[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"

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"Similarly, leptin also increased USP-2 protein expression in a dose- and time dependent manner in HepG2 cells and MCF-7 cells."

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"Although USP-2 seems to play a critical role in USP-2 expression modulated by adiponectin and leptin, the only little information regarding molecular mechanisms underlying USP-2 expression is availabl[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"

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"Leptin increases expression of p53 and USP2 in HepG2 tumor Xenograft model."

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"Herein, we present the evidence that changes in USP-2 expression by adiponectin and leptin contribute to the regulation of cyclin D1 degradation by proteasomes that impacts cell cycle modulation in ca[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"

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"In the present study, we clearly demonstrated that adiponectin and leptin modulates expression of USP-2 expression in the opposite manner, which in turn directly impacts cyclin D1 degradation (Figs. 3[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"

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"Treatment with globular adiponectin (gAcrp) decreased, whereas leptin increased USP-2 expression both in human hepatoma and breast cancer cells."

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"As shown in Fig. 4C, transfection with siRNA targeting USP-2 significantly suppressed leptin induced cyclin D1 protein expression in HepG2 cells, suggesting that increase in USP-2 expression by leptin[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"

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"While it has been shown that USP2 is involved in the regulation of cancer growth and leptin induces USP2 expression, the functional role of USP2 in leptin induced p53 expression has not been explored."