IndraLab
Statements
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"The pERK signal increase induced by BDNF or bFGF remained quantitatively similar in betaII-spectrin knockdown neurons as compared to wild type neurons (XREF_SUPPLEMENTARY, XREF_SUPPLEMENTARY and XREF_SUPPLEMENTARY), suggesting that the MPS does not act downstream of these RTKs, but likely affects their transactivation by CB1 and NCAM1."
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"A two-way ANOVA found that the i.v. drug (cocaine vs saline; F (1,25) = 4.61, p < 0.05) and the intracranial infusion (BDNF vs PBS; F (1,25) = 14.61, p < 0.001) had significant main effects on pERK (XREF_FIG) but there was no interaction between drug and infusion (F (1,25) = 1.01, p = 0.32) because BDNF increased pERK in the presence or absence of cocaine."
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"TCN-201 infusion into the prelimbic cortex inhibited the BDNF mediated increase in pERK and pGluN2A whereas Ro-25-6981 infusion into the prelimbic cortex blocked BDNF induced elevation of pERK and pGluN2B, indicating that both GluN2A- and GluN2B containing NMDA receptors underlie BDNF induced ERK activation."
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"In Experiment 2, drug-naive rats with bilateral intra-dmPFC cannulae received an intracranial infusion of BDNF or PBS and were euthanized by rapid decapitation 0.5 hr, 2 hrs, or 6 hrs post-infusion in order to demonstrate the time course over which intradmPFC BDNF would increase p-ERK, p-CREB, and p-Akt in vivo in the dmPFC (XREF_FIG)."
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"Confirmation that 0.05 and 0.005 mug/0.5 mul of TCN-201 or 0.2 and 2 mug/0.5 mul of Ro-25-6981 infused 20 min before BDNF (0.75 mug/0.5 mul and side) prevented the ability of BDNF to increase phospho-ERK expression in a dose dependent manner two hr later is presented in XREF_SUPPLEMENTARY and XREF_SUPPLEMENTARY."
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"In cultured RGCs, KLF9 requires expression of Dusp14 to suppress RGC axon growth, and knockdown of Dusp14 activity in vivo using adeno-associated virus 2 short hairpin ribonucleic acid (AAV2-anti-Dusp14-shRNA) increased BDNF-induced pERK signaling, RGC survival and the number and length of regenerating axons after optic nerve crush ."