IndraLab

Statements

USP37 increases the amount of ERK. 3 / 3
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"However, depletion of USP37 abolished the differential expression of ERK1/2 in different phases of the cell cycle (Fig. S4 B), suggesting that the cell cycle regulates ERK1/2 expression in a USP37-dependent manner."
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"Moreover, overexpression of USP37 WT or USP37 SD, but not the USP37 CS or USP37 SA mutants, restored the ERK1/2 protein level in cells treated with CDK1/2i (Fig. S3 J)."
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"In addition, reconstitution of USP37 partially rescued ERK1/2 protein levels or tumor cell growth in either CDK2-knockdown or CDK1/2i-treated cells (Fig. S4, H–K)."
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