IndraLab

Statements

USP45 inhibits V-ATPase. 3 / 3
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"We found that knockdown of USP45 dramatically enhanced the localization of V-ATPase to late endosomes and lysosomes, thereby enhancing the number of acidified lysosomes and lysosomal function.Accumulating evidence has highlighted the pivotal roles of ubiquitination and deubiquitination in governing endocytic trafficking (Piper et al., 2014)."
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"USP45 negatively regulates lysosomal activity by altering V-ATPase endolysosomal trafficking."
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"Further, we showed that depletion of dUsp45/USP45 promotes V-ATPase localization to autolysosomes, thereby enhancing lysosomal acidification and autophagic–lysosomal activity."
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