IndraLab

Statements

Celastrol inhibits KCNH2. 4 / 5
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"In addition, celastrol blocks ion conduction of cardiac Kir2.1 and hERG potassium channels and reduces channel density on cell surface upon chronic treatment, which may predict cardiotoxicity."
28664158
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"Celastrol inhibited the activities of hERG potassium channels, causal to QT interval prolongation."
33867974
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"Celastrol blocks the ion conduction of cardiac Kir2.1 and hERG potassium channels and reduces channel density on the cell surface upon chronic treatment, which may predict cardiotoxicity."
33015082
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"Chronic inhibition of cardiac Kir2.1 and HERG potassium channels by celastrol with dual effects on both ion conductivity and protein trafficking."
16407206