IndraLab

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Progesterone activates KCNH2. 2 / 2

| 2

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"Application of 2-hydroxypropyl-beta-cyclodextrin (a sterol binding agent) or overexpression of Rab9 rescued the progesterone induced HERG trafficking defect and ER stress."

21525004

➶

reach

"Further, it has been demonstrated that progesterone may modulate hERG folding in the ER and Golgi trafficking by regulating intracellular cholesterol homeostasis, thus offering a possible mechanism for arrhythmic risk in late-stage pregnancy 87."

23459091

INDRA sources:

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IndraLab

Statements

Progesterone activates KCNH2. 2 / 2

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