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OTUB1 inhibits IL15. 3 / 3

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"Deubiquitinase Otub1 negatively regulates IL-15 signaling in CD8 T cells and NK cells."

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"Otub1 deficiency in mice causes aberrant responses of CD8 T cells to IL-15, rendering naive CD8 T cells hyper-sensitive to antigen stimulation characterized by enhanced metabolic reprograming and effector functions."

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"Xiaofei Zhou et al. identified that the deubiquitinase OTUB1 negatively regulates IL-15 signaling in CD8 + T cells and NK cells activation and reprogramming [ 63 ]."

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OTUB1 inhibits IL15. 3 / 3

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