IndraLab

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PKA activates KCNH2. 16 / 17
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"Our finding that the in-vitro translation system was not able to recapitulate PKA dependent enhancement of HERG further points to the existence of a cellular co-factor that is not present in the reticulocyte lysate system."
22613764
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"We confirmed that fine-tuning lipophilicity and basic pKa by modifying the benzyl-group and introducing different substituents on the aliphatic nitrogen sidechain decreases both hERG inhibition and metabolic clearance."
35041296
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"A PKA inhibitor targeted to the ER surface (termed p4PKIg) completely abolished PKA mediated augmentation of HERG in HEK293 cells as well as rat neonatal cardiomyocytes."
21536683
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"Our results indicated that AKAP5 binds to PKA to target the HERG channel, thus assisting in the up-regulation of HERG by chronic PKA signaling.This study has a number of limitations."
32173522
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"Activation of cAMP and PKA increased the abundance of HERG signal in both groups to a comparable degree as in cells transfected with HERG alone with no statistically significant difference."
22613764
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"For the PKA mediated increase in HERG abundance, PKA activity must be localized to the surface of the ER [XREF_BIBR]."
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"As Kv11.1 channel activity is enhanced by cAMP‐dependent protein kinase A (e.g., Chen et al., 2010) we speculated if Kv11 channels contributed functionally to β‐adrenoceptor‐mediated responses."
36750122
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"It is known that the hERG K + channel can be modulated by cAMP and PKA."
23029432
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"This suggests that AKAP5 is involved in the PKA-related continuous up-regulation of the HERG potassium channels, which provides a possible relationship between AKAP5 and the prevention of LQTS.The rap[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
32173522
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"Our data suggest that mainly PKA is mediating the shift of the HERG activation kinetics."
9737994
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"For example, it is known that transcription levels of Kv1.5 are modulated by glucocorticoids, that Kv3.4 expression is upregulated by skeletal muscle innervation, and that PKA phosphorylation at the surface of the ER augments hERG biosynthesis."
22754540
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"In light of the previous findings by Chen et al 2009 that the HERG mRNA remains stable and does not increase with 24 hours of kinase activation, our findings suggest that a short lived and/or newly transcribed protein is required for the PKA mediated increase in HERG protein abundance [XREF_BIBR]."
22613764
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"3.7 14-3-3 interactions do not alter the PKA mediated increase in HERG abundance."
22613764
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"Just how PKA activation enhances an already actively translating HERG channel is yet to be precisely determined."
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"Previous work showed that sustained protein kinase A (PKA) activity augments HERG protein abundance by a mechanism that includes enhanced protein translation."
21536683
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"3.8 MiRP (KCNE) proteins in the cAMP and PKA augmentation of HERG."
22613764