IndraLab

Statements

PKA activates KCNH2. 15 / 16
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"For example, it is known that transcription levels of Kv1.5 are modulated by glucocorticoids, that Kv3.4 expression is upregulated by skeletal muscle innervation, and that PKA phosphorylation at the surface of the ER augments hERG biosynthesis."
22754540
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"Previous work showed that sustained protein kinase A (PKA) activity augments HERG protein abundance by a mechanism that includes enhanced protein translation."
21536683
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"Just how PKA activation enhances an already actively translating HERG channel is yet to be precisely determined."
22613764
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"Our finding that the in-vitro translation system was not able to recapitulate PKA dependent enhancement of HERG further points to the existence of a cellular co-factor that is not present in the reticulocyte lysate system."
22613764
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"3.7 14-3-3 interactions do not alter the PKA mediated increase in HERG abundance."
22613764
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"We confirmed that fine-tuning lipophilicity and basic pKa by modifying the benzyl-group and introducing different substituents on the aliphatic nitrogen sidechain decreases both hERG inhibition and metabolic clearance."
35041296
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"For the PKA mediated increase in HERG abundance, PKA activity must be localized to the surface of the ER [XREF_BIBR]."
22613764
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"In light of the previous findings by Chen et al 2009 that the HERG mRNA remains stable and does not increase with 24 hours of kinase activation, our findings suggest that a short lived and/or newly transcribed protein is required for the PKA mediated increase in HERG protein abundance [XREF_BIBR]."
22613764
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"Our data suggest that mainly PKA is mediating the shift of the HERG activation kinetics."
9737994
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"AKAP5 anchors PKA to enhance regulation of the HERG channel."
32173522
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"These results provide evidence for a novel mechanism which AKAP5 anchors PKA to up-regulate the HERG channel protein."
32173522
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"3.8 MiRP (KCNE) proteins in the cAMP and PKA augmentation of HERG."
22613764
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"Activation of cAMP and PKA increased the abundance of HERG signal in both groups to a comparable degree as in cells transfected with HERG alone with no statistically significant difference."
22613764
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"A PKA inhibitor targeted to the ER surface (termed p4PKIg) completely abolished PKA mediated augmentation of HERG in HEK293 cells as well as rat neonatal cardiomyocytes."
21536683
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"It is known that the hERG K + channel can be modulated by cAMP and PKA."
23029432