IndraLab

Statements

CAV3 activates SCN5A. 3 / 3
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"Caveolin-3 suppresses late sodium current by inhibiting nNOS dependent S nitrosylation of SCN5A."
23541953
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"Mutations in Caveolin-3 induce kinetic alterations of the Nav1.5 current which result in accentuation of the depolarizing “window current” substantiating a new pathogenic mechanism for QT-prolongation[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
18336833
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"CAV3 pathogenic variants cause an LQT3-like accentuation in late sodium current ( SCN5A , Nav1.5, LQT3) and are associated with LQTS (LQT9) [ 4 , 7 ]."
32387251