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A database built with INDRA combining content from numerous readers and databases. This page allows you to curate the loaded statements. For more information please see the manual.

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INDRA is developed by indralabs, a part of the Harvard Medical School Laboratory of Systems Pharmacology.

This project, indra_db, is also developed by the indralab team. For more information on how we procure our sources, you can go here. This work was funded by ARO grant W911NF‐15‐1‐0544 under the DARPA Communicating with Computers program.

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USP14 decreases the amount of MDM2. 3 / 3

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"USP14 inhibition downregulates AR and PSA and increases MDM2 expression."

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"Our current study showed that IU1, a pharmacological deubiquitinating enzyme USP14 selective inhibitor, dramatically decreased MDM2 level, blocked G0/G1 to S phase transition, decreased cell growth and triggered cell apoptosis in cervical cancer cells, suggesting that targeting USP14 and MDM2 axis could be a potential strategy for cervical cancer therapy."

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"As shown above, USP14 decreases the expression and phosphorylation of MDM2."

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USP14 decreases the amount of MDM2. 3 / 3

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