IndraLab

Statements


USP12 inhibits IFI16. 3 / 3
| 3

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"Mechanistically, USP12 inhibited the proteasome-dependent degradation of IFI16 through its deubiquitinase activity, thereby maintaining IFI16 stability and promoting IFI16-STING-IRF3- and p65-mediated antiviral signaling."

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"Mechanistically, USP12 inhibited the proteasome-dependent degradation of IFI16 through its deubiquitinase activity."

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"We found that USP12 deficiency promoted the degradation of IFI16 (Fig 5E)."